Trypanosomiasis

COMPOSITION :
Each sachet contains :
Diminazene Diaceturate  1.05 gm
Cyanocobalamin BP        1.500 mg
(Vitamin B12)
Pyridoxine HCL BP          6.00 mg
(Vitamin B6)
Antipyrin up to               2.36 gm

Diminazene is highly active against Trypanosoma spp., Babesia spp. and Theileria annulate

1.05 g diminazene diaceturate sufficient for 300 kg of body weight. To be dissolved in15ml of water for the preparation of an injectable solution.

WITHDRAWAL PERIOD :

Meat : 21 days
Milk Deliver : 3 days

PACK SIZE :

1 x 10 sachet

COMPOSITION :
Each sachet contains :
Diminazene Diaceturate 10.5 gm
Cyanocobalamin BP       15.00 mg
(Vitamin B12)
Pyridoxine HCL BP         60.0 mg
(Vitamin B6)
Antipyrin up to              23.6 gm

Diminazene is highly active against Trypanosoma spp., Babesia spp. and Theileria annulate

10.5 g diminazene diaceturate sufficient for 3000 kg of body weight. To be dissolved in 150 ml of water for the preparation of an injectable solution.

WITHDRAWAL PERIOD :

Meat : 21 days
Milk Deliver : 3 days

PACK SIZE :

1 x 10 sachet

COMPOSITION :
Each g contains :
Isometamidium chloride hydrochloride 1,000 mg.

DESCRIPTION :
Isometamidium is a phenanthridine aromatic amidine with a narrow therapeutic index which has been marketed for over 30 years as both a prophylactic and a therapeutic trypanocidal agent in the field. Isometamidium chloride is used curatively at lower dosage rates, and prophylactically at higher dosage rates.

INDICATION :

ISOMID is indicated for treatment and prevention of trypanosomiasis caused by Trypanosoma spp. in Cattle, Goats, Sheep, Camels, Horses and Dogs. A preventive dosage ensures protection for 2 to 4 months. When clinical cases occur, the whole group should be treated.

CONTRAINDICATION :

ISOMID should not be administered subcutaneously.

Avoid concurrent administration of other trypanocidal drugs, particularly diminazene aceturate.

Avoid underdosing.

SIDE EFFECTS :
Individual sensitivity to ISOMID is possible.

DOSAGE AND ADMINISTRATION :

For parenteral administration.

Dissolve the content of one sachet of ISOMID (1 g) in 50 ml or 100 ml of sterile water for injection to obtain a 2% (20 mg/ml) or a 1% (10 mg/ml) solution, respectively. Repeated injections are needed at intervals of 10 to 12 weeks or more, depending on the level of fly challenge. Calves, Goats and Sheep : treatment : 0.25 - 0.5 mg/kg by deep IM injection.
prevention: 0.5 - 1 mg/kg by deep IM injection.
Camels : 0.5 - 0.75 mg/kg using a 1% solution by very slow IV injection.
Horses : 0.5 mg/kg by deep IM injection.
Dogs : 1 mg/kg by deep IM injection.
Deep IM injection should occur preferably in the middle third of the neck in large animals. Doses exceeding 10 ml should be injected at multiple injection sites on each side of the neck. Make sure that the syringe is completely empty before retracting it from the IM injection site. Afterwards, to prevent leakage of ISOMID into subcutaneous tissues, firm pressure must be applied on the injection site. Sheep and Goats are injected deep in their thigh muscles.

WITHDRAWAL PERIOD :

For meat : 30 days.
For milk  :  0 days.

PACK SIZE :

Sachet of 1 g.
One sachet is sufficient for the preventive treatment of 8 animals or the curative treatment of 16 animals, weighing 250 kg each